RUŌOD Lab

Stage F · Mastery and Research

Mastery course: Advanced Perfumery Chemistry

Vapor-liquid equilibrium, evaporation, odor activity, autoxidation, reactions in ethanol and mass spectra, derived.

Mastery 7 lessons After Level 7 and the Molecular Perfumery track and the Analytical Perfumery track About 6 hours of study, plus practice

0 of 7 lessons completed
By the end you will have: A research dossier predicting how one material behaves in a formula from its physical chemistry, tested against published data, with every assumption named.

Lessons

Physical chemistry of a fragrance

  1. Raoult's Law and the Headspace of a Perfume

    Derive what a perfume puts into the air from its liquid composition: mole fractions, partial pressures, activity coefficients and why water matters.

    55 min · Exercise: Predict a headspace, then compare it with published data

  2. Evaporation Thermodynamics: Clausius–Clapeyron at the Blotter

    How temperature and enthalpy of vaporization set evaporation speed, why skin warmth reorders a perfume, and a simple model of how long each material lasts.

    55 min · Exercise: Model a drydown, then test it on blotters

  3. Odor Activity Values: From Concentration to Impact

    Turn a partial pressure into an air concentration and an odor activity value, then into perceived intensity with Stevens' law, and see where it misleads.

    50 min · Exercise: Rank an accord by OAV, then test the ranking by omission

Reactivity and identification

  1. Autoxidation Kinetics and Accelerated Aging

    The radical chain behind terpene oxidation, what antioxidants interrupt, and the Arrhenius arithmetic that accelerated stability tests rely on — and misuse.

    55 min · Exercise: Audit an accelerated-aging claim

  2. Equilibria in the Bottle: Acetals, Schiff Bases and Esters

    Why aldehydes form acetals in ethanol, how water and acid move the equilibrium, and how Schiff bases and transesterification change an aging perfume.

    50 min · Exercise: Separate equilibrium from oxidation in a macerating sample

  3. Fragmentation Mechanisms in Terpenoid Mass Spectra

    Read an electron-ionization spectrum as chemistry: alpha cleavage, McLafferty and retro-Diels–Alder, with limonene, linalool and pinene worked.

    60 min · Exercise: Rationalize five reference spectra

  4. Mastery Project: A Physical-Chemistry Dossier

    The chemistry course project: predict one material's behavior in a formula from first principles, then test each prediction against data or the bench.

    40 min · Exercise: The Advanced Perfumery Chemistry project